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Tytuł oryginału: Effect of repeated treatment with reboxetine on the central ŕ1-adrenergic and dopaminergic receptors.
Autorzy: Rogóż Zofia, Margas Wojciech, Skuza Grażyna, Solich Joanna, Kuśmider Maciej, Dziedzicka-Wasylewska Marta
Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.593-603, il., tab., bibliogr. 48 poz.
Sygnatura GBL: 313,156

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    Streszczenie angielskie: Reboxetine (REB) is a member of a new class of antidepressants drugs, which selectively inhibit the neuronal reuptake of noradrenaline. It is devoid of any affinity for neurotransmitter receptors nor does it inhibit monoamine oxidases A or B. Since our earlier studies have shown that antidepressant drugs administered repeatedly increase the responsiveness of ŕ1-adrenergic receptors and induce the up-regulation of postsynaptic dopamine D2/D3 receptors in the rat brain, we designed the present experiments to determine whether repeated administration of REB evokes similar effects. The experiments were carried out on male Wistar rats. REB was administered at a dose of 10 mg/kg (or 30 mg/kg in some cases) once or repeatedly (twice daily for 14 days). The obtained results show that REB administered repeatedly increased exploratory behavior induced by phenylephrine and potentiated the hyperlocomotion induced by D-amphetamine. These behavioral effects indicate the hyperresponsiveness of 1-adrenergic receptors. Biochemical studies did not show any changes in the binding parameters of [3H]prazosin (Bmax or Kd), but the ability of the ŕ1-adrenergic receptor agonist, phenylephrine, to complete for these sites was significantly increased upon repeated administration of REB. Locomotor activity induced by quinpirole was not changed, although there was a potentiation of 7-OH-DPAT-induced locomotor hypereactivity in rats receiving repeated administration of REB. At the same time no significant changes in the binding of [3H]quinpirole and [3H]7-OH-DPAT, or at the level of mRNA...

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