Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: MAJKA
Liczba odnalezionych rekordów: 6



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Tytuł oryginału: Oral cavity as a potential source of gastric reinfection by Helicobacter pylori.
Autorzy: Karczewska Elżbieta, Konturek Joanna E., Konturek Peter C., Cześnikiewicz Marta, Sito Edward, Bielański Władysław, Kwiecień Nina, Obtułowicz Wojciech, Ziemniak Witold, Majka Jolanta, Hahn Eckhart G., Konturek Stanisław J.
Źródło: Dig. Dis. Sci. 2002: 47 (5) s.978-986, il., tab., bibliogr. 24 poz.
Sygnatura GBL: 310,037

Hasła klasyfikacyjne GBL:
  • stomatologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Helicobacter pylori (Hp) is a common pathogen colonizing the a gastric mucosa, but some reports indicated that it may also be found in the oral cavity, which could serve as a reservoir of the bacteria and a source of gastric reinfection. Accordingly, we aimed to study whether the oral cavity, particularly gingival pockets, are colonized by Hp and whether it could be the source of gastric reinfection. We studied 329 patients with dyspeptic symptoms (257 with chronic gastritis, 15 with gastric ulcer. and 57 with duodenal ulcer). The [**13C]urea breath test (UBT), gastroscopy, and Hp culture from gastric biopsies were carried out, and material was collected from the oral cavity (gingival pocket) for bacteriological culture and genomic DNA studies. The serum was obtained for anti-Hp IgG and anti-CagA assays and saliva for anti-Hp IgA determination using the ELISA technique. bacteria in material from gingival pockets and biopsies from the corpus and antrum of stomach of 30 DU patients before and after Hp eradication were also examined by PCR technique, using primers specific for 16S rNA. All Hp-positive patients (276) were subjected to one week of triple therapy (omeprazole 2 x 20 mg twice a day, clarithromycin 2 = 500 mg twice a day, and metronidazole 2 x 500 mg twice a day). The measurements descrived above were then repeated at four weeks and six months. Bacterkilogical culture showed the prsence of Hp in the material from oral cavity in about 50 p.c. of patients, whereas UBT, used as a gold standard, revealed gastric Hp infection in about 84 p.c. of these patients...


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    Tytuł oryginału: Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells.
    Autorzy: Baj-Krzyworzeka Monika, Majka Marcin, Pratico Domenico, Ratajczak Janina, Vilaire Gaston, Kijowski Jacek, Reca Ryan, Janowska-Wieczorek Anna, Ratajczak Mariusz Z.
    Źródło: Exp. Hematol. 2002: 30 (5) s.450-459, il., tab., bibliogr. 39 poz.
    Sygnatura GBL: 305,749

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: objective. peripheral blood plateled-derived microparticles (PMPs) circulate in blood and may interact directly with target cells affecting their various biological functions. methods. To investigate the effect of human PMPs on hematopoiesis, we first phenotyped them for expression of various surface molecules and subsequently studied various biological responses of normal stem/progenitor (CD34+) and more differentiated precursor cells as well as several leukemic cell lines to PMPs. Results. We found that, in addition to platelet-endothelium attachment receptors (CD41, CD61 and CD62), PMPs express G-protein-coupled seven transmembrane-span receptors such as CXCR4 and PAR-1; cytokine receptors including TNF-RI, TNF-RII, and CD95; and ligands such as CD40L and PF-4. Moreover, we found that several of these receptors could be transferred by PMPs to the membranes of normal as well as malignant cells and observed that PMPs: 1) chemoattract these cells, 2) increase their adhesion, proliferation, and survival, and 3) activate in these cells various intracellular signaling cascades including MAPK p42/44, PI-3K-AKT, and STAT proteins. The biological effects of PMPs were only partly reduced by heat inactivation or trypsin digest, indicating that, in addition to the protein components of PMPs, lipid components are also responsible for their biological activity. conclusion. We conclude that PMPs modulate biological functions of hematopoietic cells and postulate that they play an important but as yet not fully understood role in intracellular cross-talk in hematopoiesis...


    3/6

    Tytuł oryginału: Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets.
    Autorzy: Majka Marcin, Ratajczak Janina, Villaire Gaston, Kubiczek Krystyna, Marquez Leah A., Janowska-Wieczorek Anna, Ratajczak Mariusz Z.
    Źródło: Exp. Hematol. 2002: 30 (7) s.751-760, il., tab., bibliogr. 51 poz.
    Sygnatura GBL: 305,749

    Hasła klasyfikacyjne GBL:
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective: The development of megakaryocytes is regulated by thrombopoietin (TPO), which binds to the c-mpl receptor, and by several other cytokines such as interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), cilliary neurotropic factor (CNTF), and oncostatin (OSM), which bind to gp130 protein-coupled receptors. We attempted to identify signal transduction pathways activated by these factors in normal human megakaryocytes. Materials and methods: To better understand the role of these factors in normal human megakaryopoiesis we studied their effect on 1) purified human bone marrow-derived CD34+ cells, 2) human ŕIIbá3+ cells (shown by immunophenotypical and morphological criteria to be megakaryoblasts), which had been expanded ex vivo from CD34+ cells in chemically defined artificial serum, and 3) gel-filtered human peripheral blood platelets. Further, in an attempt to correlate the influence of these factors on cell proliferation and survival activation of signal transduction pathways, we evaluated their effect on the phosphorylation of MAPK p42/44 and activation of PI-3K-AKT and JAK-STAT proteins in these various cell types. Results: Using serum-free liquid cultures, we found that only TPO and IL-6 protected CD34+ cells and megakaryocytes from undergoing apoptosis (decrease in annexin-V binding, PARP cleavage, and activation of caspase-3). Moreover, only TPO when used alone and IL-6 only when used in combination with TPO, stimulated the growth of human colony-forming unitmegakarocytes (CFU-Meg) in semisolid serum-free medium...


    4/6

    Tytuł oryginału: Rozwój diagnostyki i terapii mukowiscydozy.
    Tytuł angielski: Progress in diagnostics and therapy of cystic fibrosis.
    Autorzy: Majka L., Pawlak J., Młynarczyk W.
    Źródło: Post. Aerozoloter. 2002: 10 (1) s.5-12, il., tab., bibliogr. 30 poz., sum.
    Sygnatura GBL: 306,509

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Objawy mukowiscydozy zwracały uwagę już od czasów Średniowiecza. Jednak historia badań nad patofizjologią CF obejmuje wiek XX. Racjonalną terapię wprowadzono natomiast w drugiej połowie ubiegłego stulecia. Artykuł jest zarysem dziejów badań nad mukowiscydozą, dzięki którym zdefiniowano chorobę i wprowadzono leczenie jej głównych objawów.

    Streszczenie angielskie: The symptoms of cystic fibrosis were noticed already in Middle Ages. The majority of investigations on pathophysiology of CF were done in XX century. Comprehensive treatment was implemented after 1950. This article describes major facts in the history of diagnosis and therapy of cystic fibrosis.


    5/6

    Tytuł oryginału: Influence of chronic Helicobacter pylori infection on ischemic cerebral stroke risk factors.
    Autorzy: Majka Jolanta, Róg Teresa, Konturek Peter C., Konturek Stanisław J., Bielański Władysław, Kowalsky Marek, Szczudlik Andrzej
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR675-CR684, il., tab., bibliogr. 100 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Infection by Helicobacter pylori (Hp) has been linked to extradigestive pathologies including ischemic cerebral disease. The aim of our study was to assess the relationship between chronic Hp infection and ischemic stroke risk factors. Material/Methods: 80 patients (pts) aged 60 - 75 years with ischemic stroke confirmed by CT scans (group I) and 80 age- and gender-matched healthy controls (group II) were included into trial. Atherosclerotic plaques from 20 Hp positive pts were obtained at carotid endarterectomy for Hp DNA assessment by PCR. In all groups following parameters were determiend; 1) the prevalence of Hp infection using 13C-Urea Breath Test (UBT), 2) plasma anti-Hp and anti-CagA IgG and interleukin-8 (IL-8), and 3) palsma lipids and fibrinogen. Hp positive pts and controls received one-week anti-Hp therapy and after six months total cholesterol, low-density lipoprotein (LDL)-cholesterol, fibrinogen and IL-8 levels were re-examined. Results: Hp infection was detected by UBT in 83.75 p.c. of stroke pts but only in 65 p.c. of controls. DagA seropositivity was also significantly higher in stroke pts (57.5 p.c.) than in controls (33.75 p.c.). Plasma levels of cholesterol, LDL-cholesterol and fibrinogen as well as IL-8 were significantly higher in Hp positive subjects, especially in pats with ischemic stroke. Six months following successful anti-Hp therapy, the plasma levels of total cholesterol, LDL-cholesterol, fibrinogen and IL-8 were significantly lower than those in Hp positive stroke pts and contorls. Conclusions: Hp infection represents risk factor of ischemic stroke via an interaction of Hp cytotoxings of cytokines with atherosclerotic plaques in carotic arteries.


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    Tytuł oryginału: Zasady rozpoznawania i leczenia mukowiscydozy.
    Tytuł angielski: Diagnosis and treatment of cystic fibrosis.
    Opracowanie edytorskie: Milanowski Andrzej (Oprac.), Pogorzelski Andrzej (oprac.), Orlik Teresa (oprac.), Piotrowski Robert (oprac.), Walkowiak Jarosław (oprac.), Skorupa Wojciech (oprac.), Witt Michał (oprac.), Latoś Tadeusz (oprac.), Żebrak Jerzy (oprac.), Nowakowska Anna (oprac.), Sands Dorota (oprac.), Mazurczak Tadeusz (oprac.), Majka Lucyna (oprac.), Minarowska Alina (oprac.), Socha Jerzy (oprac.).
    Źródło: Stand. Med. Lek. Pediatr. 2002: 4 (10) s.600, 602, 604-612, tab., bibliogr. 4 poz.
    Sygnatura GBL: 313,619

    Hasła klasyfikacyjne GBL:
  • pediatria

    Typ dokumentu:
  • standard

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Przedstawiono współczesną klasyfikację mukowiscydozy, zasady diagnostyki i kompleksowego leczenia chorych. Podano zasady opieki ambulatoryjnej i szpitalnej w ośrodkach specjalistycznych i referencyjnych.

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