Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
LIPKOWSKI
Liczba odnalezionych rekordów:
3
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1/3
Tytuł oryginału:
Direct antimicrobial properties of substance P.
Autorzy:
Kowalska
Katarzyna,
Carr
Daniel B.,
Lipkowski
Andrzej W.
Źródło:
Life Sci. 2002: 71 (7) s.747-750, il., tab., buibliogr. 14 poz.
Sygnatura GBL:
304,948
Hasła klasyfikacyjne GBL:
mikrobiologia
farmacja
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Streszczenie angielskie:
The structural similarity between substance P (SP, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Gly-Leu-Met-NH2) and Arg/Pro rich bactericidal peptides suggests a possible direct effect of SP on invasive microbes. We now present evidence that substance P possesses direct antimicrobial activity, highest against S. aureus. A substance P antagonist allso possess such activity but while less potent than substance P agonist S. aureus, is more potent than substance P against C. albicans. Our data also show that the endogenous peptides bradykinin and neurotensin, that also play role in modulation of the host-defense system in situ, have antimicrobial properties but are less potent than substance P.
2/3
Tytuł oryginału:
Biological properties of a new fluorescent biphalin fragment analogue.
Autorzy:
Lipkowski
Andrzej W.,
Misicka
Aleksandra,
Kosson
Dariusz,
Kosson
Piotr,
Lachwa-From
Magdalena,
Brodzik-Bieńkowska
Agnieszka,
Hruby
Victor J.
Źródło:
Life Sci. 2002: 70 (8) s.893-897, il., tab., bibliogr. 16 poz.
Sygnatura GBL:
304,948
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
Streszczenie angielskie:
Previous studies of stsurcture-activity of biphalin defined fragments which expressed the full biological potency of the parent compound. The most simple fragment was Tyr-D-Ala-Gly-Phe-NH-HH - X, where X = Phe, but it also could be other hydrophobic amino acids. This paper presents data that replacement of the phenylalanine with a dansyl (X = DNA) groups gives an analogue (AA20116) that fully preserves the high affinity of the initial analogue for both ć and ë opiioid receptors. In the tail flick test in rats, intrathecal injection of the compound produces strong antinociception, comparable to the parent biphalin. Cecause AA2016 contains a strong fluorescent group, it can be a very useful tool for prospective studies in vivo, including biological barrier permeability, tissue distribution, metabolism and receptor-ligand complex formation.
3/3
Tytuł oryginału:
Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine. P. 2: Synthesis and pharmacological activity of 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-ŕ][1,3,5]triazines.
Autorzy:
Matosiuk
Dariusz,
Fidecka
Sylwia,
Antkiewicz-Michaluk
Lucyna,
Lipkowski
Janusz,
Dybala
Izabela,
Koziol
Anna E.
Źródło:
Eur. J. Med. Chem. 2002: 37 (9) s.761-772, il., tab., bibliogr. 12 poz.
Sygnatura GBL:
312,629
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
myszy
Streszczenie angielskie:
Synthesis and pharmacological activity of 1,6-diaryl-5,7 (1H)dioxo-2,3-dihydroimidazo-[1,2-ŕ][1,3,5]triazines (C) are presented. The title compounds were obtained from 1-aryloimidazolinurea derivatives in cyclization reaction with difunctional carbonyl reagents - phosgene (method I) or carbonyldiimidazole (CDI) (method II). Their molecular structures were confirmed by the X-ray analysis of 1-phenyl-6-(4-chlorophenyl)-5,7(1H)-dioxo-2,3-dihydroimidazo[1,2-ŕ][1,3,5]triazine C2) crystals. Compounds C exhibited significant depressive action on the central nervous system (CNS) of the laboratory animals, correlated with very low acute toxicity (LD50 2000 mg kg**-1 i.p.), and showed antinociceptive activity in behavioural models. Reversion of this effect by small dose of naloxone (5 mg kg**-1) can suggest opioid-like mechanism of antinociception produced by these and other carbonyl derivatives of 1-aryl-2-iminoimidazolidine. Additionally, an effect on the serotonin neurotransmission pathway was also observed. The receptor mechanism of activity for investigated compounds was confirmed only for the opioid ć receptor in binding affinity assay test. Same tests performed for the serotonin 5-HT2 and benzodiazepine BZD receptors showed no affinity for tested compounds. The opioid-like and serotonergic activities are similar to these described earlier for chain carbonyl 1-aryl-2-iminoimidazolidine derivatives containing urea moiety, mainly due to similar chemical structure, although compounds C are not able to adopt any of the higher energy confirmations of urea derivatives...
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