Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: LEE
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: Grant : atlas anatomii
Autorzy: Agur Anne M. R., Lee Ming J.
Opracowanie edytorskie: Gielecki Jerzy S. (oprac. i tł.).
Źródło: - Wrocław, Górnicki Wydaw. Medyczne 2002, XVIII, 778 s. : il., tab., bibliogr. s. XV-XVIII, 28 cm. - Tyt. oryg. Grant's atlas of anatomy
Sygnatura GBL: 802,905

Wskaźnik treści:
  • ludzie


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    Tytuł oryginału: Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk.
    Autorzy: Benhamou Simone, Lee Won Jin, Alexandrie Anna-Karin, Boffetta Paolo, Bouchardy Christine, Butkiewicz Dorota, Brockm”ller Jurgen, Clapper Margie L., Daly Ann, Dolzan Vita, Ford Jean, Gaspari Laura, Haugen Aage, Hirvonen Ari, Husgafvel-Pursiainen Kirsti, Ingelman-Sundberg Magnus, Kalina Ivan, Kihara Masahiro, Kremers Pierre, Le Marchand Loic, London Stephanie J., Nazar-Stewart Valle, Onon-Kihara Masako, Rannug Agneta, Romkes Marjorie, Ryberg David, Seidegard Janeric, Shields Peter, Strange Richard C., Stcker Isabelle, To-Figueras Jordi, Brennan Paul, Taioli Emanuela
    Źródło: Carcinogenesis 2002: 23 (8) s.1343-1350, il., tab., bibliogr. 54 poz.
    Sygnatura GBL: 312,779

    Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Susceptibility to lung cancer may in part be attributable to inter-individual variability in metabolic activation or detopxification of tobacco carcinogens. The glutathione S-transferase M1 (GSTM1) genetic polymorphism has been extensively studied in this context; two recent meta-analyses of case-control studies suggested an association between GSTM1 deletion and lung cancer. At least 15 studies have been published after these overviews. We undertook a new meta-analysis to summarize the results of 43 published case-control studies including 18000 individuals. A slight excess of risk of lung cancer for individuals with the GSTM1 null genotype was found (odds ratio (OR) = 1.17, 95 p.c. confidence interval (CI) 1.07 - 1.27). No evidence of publication bias was found (P = 0.4), however, it is not easy to estimate the extent of such bias and we cannot rule out some degree of publications bias in our rsults. A pooled analysis of the original dsata of about 9500 subjects involved in 21 case-control studies from the international Collaborative Study on genetic Dusceptibility to Environmental Carcinogens (GSEC) data set was performed to assess the role of gsTM1 genotype as a modifier of the effect of smoking on lung cancer risk with adequate power. Analyses revealed no evidence of increased risk of lung cancer among carriers of the GSTM1 null genotype (age-, gender- and center-adjusted OR = 1.08, 95 p.c. CI 0.98 - 1.18) and no evidence of interaction between GSTM1 genotype and either smoking status or cumulative tobacco consumption.


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    Tytuł oryginału: Characterization of Clostridium perfringens strains isolated from Polish patients with suspected antibiotic-associated diarrhea.
    Autorzy: Pituch Hanna, Braak Nicole van den, Belkum Alex van, Leeuwen Willem van, Obuch-Woszczatyński Piotr, Łuczak Mirosław, Verbrugh Henri, Meisel-Mikołajczyk Felicja, Martirosian Gayane
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.BR85-BR88, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The aim of our research was to investigate the role of enterotoxin- producing anaerobic bacteria other than Clostridium difficile in the etiology of antibiotic-associated diarrhea. THis article presents data related to C. perfringens. Material/Methods: Stool samples taken from 158 patients with suspected antibiotic-associated diarrhea were specifically cultured for Clostridium difficile, Bacteroides fragilis and Clostridium perfringens. In order to associate the presence of virulence factors in the bacterial isolated thus collected with disease features, all strains were genetically and phenotypically analyzed for toxin production. All isolated C. perfringens strains were cultured in Ellner sporulation-promoting medium. Results: In 21 of the 158 patients (13 p.c.) C. perfringens could be cultivated from the fecal specimen. None of the strains produced eneterotoxin, and consequently the cpe gene was not detected by PCR in any of these strains. C. perfringens and C. difficile were cultivated from the same stool samples in 4 cases. Interestingly, in one case toxin A-negative/toxin B positive C. difficile and nonenterotoxigenic C. perfringens were co-cultured. After application of a heat shock (100řC at 30 min.) only two C. perfringens strains producing thermoresistant spores were detected. Pulsed field gel electrophoresis (PFGE) demonstrated genetic heterogenicity among the C. perfringens strains, suggesting that these bacteria were already presented upon hospital admission. Conclusion: It seems unlikely that nosocomial transfer has taken place. The relatively low incidence suggests that C. perfringens is not a major primary cause of antibiotic-associated diarrhea.

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