Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: LAURE-KAMIONOWSKA
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Proinflammatory cytokines in injured rat brain following perinatal asphyxia.
Autorzy: Maślińska Danuta, Laure-Kamionowska Milena, Kaliszek Agnieszka, Makarewicz Dorota
Źródło: Folia Neuropathol. 2002: 40 (4) s.177-182, il., tab., bibliogr. 39 poz.
Sygnatura GBL: 304,961

Hasła klasyfikacyjne GBL:
  • immunologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: In contrast to astrogliosis, which is common to injuries of the adult CNS, in the developing brain this process is minimal. Reasons postulated for this include the relative immaturity of the immune system and the consequent insufficient production of cytokines to evoke astrogliosis. To explore this hypothesis, the study was undertaken to detect the presence of some proinflammatory cytokines in the injured rat brain following perinatal asphyxia (ischaemia/hypoxia). The localisation of TNF-ŕ, IL-15, IL-17 and IL-17 recpetors was visualised by means of immunohistochemistry. In numerous neurones of the rat brain, the IL-17 appeared to be constitutively expressed. In the early period of inflammation the IL-15 was produced mainly by the blood cells penetrating the injured brain but later it was synthesised also by reactive astrocytes surroundding brain cysts and forming dense astrogliosiss around necrotic brain regions. The direct effect on astrogliosis of other estimated cytokines seems to be negligible. All the results lead to the conclusion that from all cytokines identified in the injured immature rat brain the IL-15 plays the most important role during inflammatory response and participates in the gliosis of reactive astrocytes.

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    Tytuł oryginału: Discrete glioneuronal malformative lesions in the foetal and infantile cerebral cortex.
    Autorzy: Laure-Kamionowska Milena, Maślińska Danuta, Raczkowska Barbara
    Źródło: Folia Neuropathol. 2002: 40 (4) s.183-191, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 304,961

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płód
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.

    Streszczenie angielskie: Microdysginesis is a term describing microscopic cortical cytoarchitectural abnormalities. Histologically this change shows an irregular glioneuronal tissue combination forming an abnormal structure of the cortex. The pathological features of this malformation are subtle and less well defined than other more distinctive cortical malformations. The clinical significance of these discrete glioneuronal malformations is controversial. Microscopic dysgenetic changes have been reported in cases with intractablee epilepsy but similar changes may be seen in neurologically normal adults. The purpose of our study was the investigation of microdysgenetic lesions in the developing nervous system with regard to normal migration, differentiation and maturation. The post-mortem routine investigated foetal and infantile brains were analysed histologically for the presence of discrete cortical malformations. A wide spectrum of cytoarchitectural glioneuronal malformations was found in the invetigated material. We observed leptomeningeal glioneuronal heterotopias, subpial bands of heterotopic neurones, nests of ectopic neurones in the first cortical layers, neuronal and glial clusters, small foci with irregularity of laminar structure of the cortex. Microdysgenetic changes arose from an insult occurring in the later stages of cortical development and influencing the normal fate of neuroglial cells. Various types of focal morphological and cytoarchitectonial developmental abnormalities have been associated with behavioural and neuropsychological deficits in older infants.

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