Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in different histological variants of rheumatoid synovitis.
Autorzy: Klimiuk P. A., Sierakowski S[tanisław], Latosiewicz R[obert], Cylwik B[ohdan], Skowroński J[an], Chwiecko J.
Źródło: Rheumatology 2002: 41 (1) s.78-87, il., tab., bibliogr. 50 poz.
Sygnatura GBL: 303,271

Hasła klasyfikacyjne GBL:
  • reumatologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Objective. Rheumatoid synovitis is characterized by an invasive and tissue-destructive infiltrate of lymphocytes, macrophages and synoviocytes. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) produced by these cells are important in the remodelling of the articular tissue in rheumatoid arthritis (RA). The aim of this study was to explore whether the serum concentrations of MMPs and their inhibitors were correlated with the histological appearance of the disease. Methods. Tissue and serum samples were obtained from 37 patients with clinically active RA and 30 with osteoarthritis (OA). Morphological analysis allowed the division of RA synovial specimens into two distinct types. In 22 samples only diffuse infiltrates of mononuclear cells without further microanatomical organization were found. In 15 specimens we observed lymphocytic conglomerates with germinal centre-like structures. Serum concentrations of interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), gelatinase B (MMP-9), TIMP-1 and TIMP-2 were measured with an ELISA technique. Results. Unique serum profiles of MMPs and TIMPs were identified in each of the two histological types of RA synovitis. The serum concentrations of MMP-1, MMP-3 and MMP-9 were higher in RA patients than in OA patients used as a control group (P 0.001 for all comparisons). These three MMPs dominated in the serum of RA patients with follicular synovitis compared with those diffuse synovitis (P 0.05, P 0.01 and P 0.001 respectively)...


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    Tytuł oryginału: Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis.
    Autorzy: Klimiuk P. A., Sierakowski S., Latosiewicz R., Cylwik J. P., Cylwik B., Skowroński J., Chwiecko J.
    Źródło: Ann. Rheum. Dis. 2002: 61 (9) s.804-809, il., tab., bibliogr. 46 poz.
    Sygnatura GBL: 310,264

    Hasła klasyfikacyjne GBL:
  • reumatologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Cell adhesion molecules and endothelial growth factors have an important role in the infiltrating of rheumatoid synovium with mononuclear cells, leading to the initiation and progression of the disease. Objective: To investigate whether the serum profile of soluble adhesion molecules and of vascular endothelial growth factor (VEGF) is associated with the histological apperance of rheumatoid arthritis (RA). Methods; Serum levels of soluble intercellular adhesion molecule-1 (slCAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (sE-selectin), and VEGF were assessed by enzyme linked immunosorbent assay (ELISA) in 40 patients with RA and 32 patients with osteoarthritis (OA). Results: Histological analysis of synovium specimens distinguished two types of rheumatoid synovitis. Twenty four RA samples presented diffuse infiltrates of mononuclear cells without any further microanatomical organisation, whereas in the remaining 16 samples lymphocytic follicles with germinal centrelike structures were identified. In comparison with patients with OA, constituting a control group, higher serum concentrations of slCAM-1 (p 0.001), sE-selectin (p,0.01), and VEGF (p0.001) were detected in patients with RA. Raised concentrations of slCAM-1, and VEGF dominated in the serum of patients with RA with follicular synovitis compared with those with diffuse synovitis (p 0.01 for all comparisons). The serum concentrations of slCAM-1, sVCAM-1, and VEGF correlated with markers of disease activity such as the erytchrocyte sedimentation rate and C reactive ...


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    Tytuł oryginału: Analiza stężenia metaloproteinaz i tkankowych inhibitorów metaloproteinaz w surowicy chorych z różnymi postaciami histologicznymi reumatoidalnego zapalenia stawów
    Autorzy: Klimiuk Piotr A., Latosiewicz Robert, Sierakowski Stanisław, Cylwik Bohdan, Skowroński Jan, Chwiećko Justyna
    Źródło: W: Ortopedia i traumatologia u progu nowego Millenium - Bydgoszcz, 2002 s.334-335, tab. - 34 Zjazd Naukowy Polskiego Towarzystwa Ortopedycznego i Traumatologicznego pt. Ortopedia i traumatologia u progu nowego Millenium Bydgoszcz 18-21.09. 2002
    Sygnatura GBL: 802,225

    Hasła klasyfikacyjne GBL:
  • reumatologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie

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