Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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Tytuł oryginału:
Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.
Autorzy:
Nieborowska-Skorska
Małgorzata,
Hoser
Grażyna,
Kossev
Plamen,
Wasik
Mariusz A.,
Skorski
Tomasz
Źródło:
Blood 2002: 99 (12) s.4531-4539, il., bibliogr. 68 poz.
Sygnatura GBL:
301,770
Hasła klasyfikacyjne GBL:
onkologia
hematologia
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
zwierzęta
myszy
in vitro
Streszczenie angielskie:
BCR/ABL oncogenic tyrosine kinase activates STAT5, which plays an important role in leukemogenesis. The downstream effectors of the BCR/ABL- STAT5 pathway remain poorly defined. We show here that expression of the antiapoptic protein A1, a member of the Bcl-2 family, and the serine/threonine kinase pim-1 are enhanced by CRB/ABL. This up-regulation requires activation of STAT5 by the signaling from SH3 + SH2 domains of the BCR/ABL. Enhanced expression of A1 and pim-1 played a key role in the BCR/ABL-mediated cell protection from apoptosis. In addition, pim-1 promoted proliferation of the BCR/ABL-transformed cells. Both A1 and pim-1 were required to induce interleukin 3-independent cell growth, inhibit activation of caspase 3, and stimulate cell cycle progression. Moreover, simultaneous up-regulation of both A1 and pim-1 was essential for in vitro transformation and in vivo leukemogenesis mediated by BCR/ABL. These data indicate that induction of A1 and pim-1 expression may play a critical role in the BCR/ABL - depenendent transformation.
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