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Tytuł oryginału: Is the lung cancer among the hereditary malignancies?
Autorzy: Krawczyk Paweł, Michnar Marek, Kieszko Robert, Król Anna, Wójcik Magdalena, Chocholska Sylwia, Milanowski Janusz
Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.151-157, il., bibliogr. 17 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
Sygnatura GBL: 304,313

Hasła klasyfikacyjne GBL:
  • genetyka
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Cancer familial agregation (CFA) reflects an inherited predisposition to the development of the benign and malignant tumours. In the classification, the most frequent are the hereditary breast, ovarian and colerated cancers, while the hereditary lung cancer (HLC) is not fully defined as a disorders of a genetic ground. The research involved a group of 92 patients suffering from the lung cancer and one of 80 subjects with chronic obstructive pulmonary disease (COPD) as a control. Information from the questionnaire was used for drawing the genealogies considering the incidence of different types of cancers in the particular family. 19.55 p.c. families fulfilled criteria of CFA and 3.25 p.c. - of HLC in the lung cancer patients group. In contrast with the first group, only 3.75 p.c. families fulfilled the criteria of CFA and 1.25 p.c. families - of HLC in COPD patients group. The patients with lung cancer had greater overall risk of this cancer than the patients with COPD providing that the neoplams appeared in the first-degree relatives (OR=3.09, P=0.037). The crude odds ratio of lung cancer individuals having one family member with lung cancer was 2.25 in comparison with COPD subjects (P=0.05). On the basis of the results above, it can be assumed that the lung cancer may belong to the hereditary malignancies.

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