Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Liczba odnalezionych rekordów: 7



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Tytuł oryginału: Peritonitis in peritoneal dialysis
Autorzy: Voinescu C. G., Khanna R.
Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[245-260], tab., bibliogr. 94 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    2/7

    Tytuł oryginału: Chemoprotection profiles of sodium thiosulfate on methyl methanesulfonate-induced mutagenesis of bacteriophage T4.
    Autorzy: Malik Ajmaluddin, Khan Asad Ullah, Lal Sunil Kumar
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR212-BR220, il., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: The alkylation of nucleic acids is primarily responsible for chemical carcinogenesis. Even during disease treatment, several alkylating drugs interact with nucleic acids and cause severe toxic effects. Thus good chemoprotectants are necessary. For our study we chose a simple model organism, bacteriophage T4 (a nucleoprotenic particle), and alkylating agent methyl methanesulfonate (MMS) to study its lethal effects. Sodim thiosulfate (STS), used as a chemoprotectant, has been tested against alkylating drugs. Bacteriphage T4Do were exposed to different molarities of MMS for several pre-termination incubations. Alkylation reactions were stopped with different concentrations of STS at given pre-termination incubation periods and further incubated up to 24 hours. The viability (survival frequency) of phage T4 was studied at various post-termination intervals by plaque count assay. Our results show that the survival frequency is strongly influenced by MMS dosage and exposure time. However, the antidotal effect of STS on MMS-induced lethality directly corresponds to STS dosage. Survival frequencies with 1 p.c. quench solution were lower than with 5 p.c. quench solution at all molarities of MMS and at different pre-and post-termination periods. Our studies confirmed the role of STS in the cytoprotection of bacteriophage T4. In the presence of 1 p.c. STS, a moderate inhibition in cytotoxicity was observed, while 5 p.c. STS exhibited a significant inhibition against the cytotoxic activity of MMS, presumably due to a rapid covalent binding of the methyl group (carbocation - an electrophile ) of MMS with the nucleophilic sulfur atom of STS.

    3/7

    Tytuł oryginału: Activity of adenosine deaminase and its isoforms in pleural fluid in tuberculous pleuritis.
    Autorzy: Andreasyan Nune A., Hairapetian Hripsime L., Sargisova Yelizaveta G., Mardanyan Sona S., Badalyan Lena T., Khanoyan Armen S.
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR708-CR712, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: The problem of tuberculosis is increasing in a number of countries. Adenosine deaminase activity is considered in many clinics to be avaluable biochemical test of this pathology. Considerable research has been devoted to the activity of enzyme isoforms as significant tests for diagnosing tuberculosis. Material/Methods: The leve of adenosine deaminase and teh activity of its two isoenzymes in the pleural fluids of patients with tuberculous and non-tuberculous pleurisy were compared. Results: The adenosine deaminase level in tuberculous pleural effusions was higher than in non-tuberculous pleural effusions. The data we obtained suggest that the enzyme acitavity level could be a very reliable test in the differential diagnosis of tuberculous pleurisy in the Armenian population. The activity of isoenzymes ADA1 adn ADA2, or their ratios to the total ADA actiavity, throug valuable information, has no diagnostic advantage over total ADA activity in daignosing this pathology. Conclusions: The results clearly point up the value of using a total ADA activity assay in Armenian clinics for the differential daignosis of tuberculous pleurisy. Determinations of the activity level of the ADA1 adn ADA2 isoenzymes provide no diagnostic advantage over total ADA activity.

    4/7

    Tytuł oryginału: Differences in the effects of haloperidol and clozapine on brain serotonin and dopamine metabolism and on tests related to extrapyramidal funcitons in rats.
    Autorzy: Haleem Darakhshan J., Batool Farhat, Khan Nadia H., Kamil Noor, Ali Obaid, Saify Zafar S., Haleem Mohammad A.
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR354-BR361, il., bibliogr. 51 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • neurologia
  • psychiatria i psychologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: An important goal of current neuroleptic research is to develop antipsychotic compounds with a low incidence of extrapyramidal side effects (EPS). Clozapine, the first of the atypical antipsychotics to be proven effective in treatment-resistant schizophrenia, is reported to produce less EPS than typical neuroleptics, such as haloperidol. Material/methods: The present study compares the neurochemical profiles of clozapine and haloperidol in rats. Animals injected (i.p.) with haloperidol or clozapine were sacrificed 1h later to collect brain samples. Neurochemical estimations were carried out by HPLC-EC. Results: Administration of haloperidol at doses of 1.0, 2.5 and 5.0 mg/kg increased the concentration of homovanillic acid (HVA), a metabolite of dopamine (DA), in the stratum and rest of the brain. Clozapine-injected rats (2.5, 5.0 and 10.0 mg/kg) showed smaller increases in the striatum, but not in the rest of the brain. Dihydroxyphenylacetic acid (DOPAC), another DA metabolite not affected by haloperidol, increased in teh striatum and decreased in the rest of the brain of clozapine-injected rats. 5-Hydroxyindoleacetic acid, the predominant metabolite of serotonin, increased with haloperidol and dereased with clozapine. A high dose of haloperidol (5.0 mg/kg) increased DA and 5-HT, while and equivalent does of clozapine (10.0mg/kg) decreased levels in the rest of the brain. The effects of both drugs on the HVA/5-HIAA and DOPAC/5-HIAA ratios were also different. Conclusions: THe differing activites of the two drugs at DA and serotonin receptors implies an important role for serotonin in treatment-resistant schizophrenia and a lower incidence of EPS.

    5/7

    Tytuł oryginału: Oxytocin antagonists for tocolysis in preterm labour - a systematic review.
    Autorzy: Coomarasamy Aravinthan, Knox Ellen M., Gee Harry, Khan Khalid S.
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.RA268-RA273, tab., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Background: Oxytocin antagonists have been shown to inhibit uterine contractions and delay preterm delivery. Our objective was to examine the clinical effectiveness and safety of oxytocin antagonists for tocolysis in preterm labour. Material/Methods: We searched MEDLINE, EMBASE, the Cochrane Controlled Trials Register and Science Citation Idnex using the following Medical Subject Headings and textwords: oxytocin (antagonists and inhibitors), atosiban, antocin, oxytocin antagonists, oxytocin receptor antagonists and oxytocin inhibitors. All randomised controlled trials that compared effectiveness and safety of atosiban with a placebo or another tocolytic in women with threatened or actual preterm labour were included. The primary outcome measure was the proportion of women undelivered by 48 hours from the commencement of treatment. Resutls: Six articles met the inclusion criteria - two compared atosiban to placebo and four atosiban to a beta-agonsit. Meta-analysis showed a signficant increase in the proportion of women undelivered by 48 hours in women receiving atosiban compared to placebo (RR 1.13, 95 p.c. CI 1.02, 1.26). When compared with beta-agonists, atosiban increased the proprtion of women undelivered by 48 hours, but this trend did not reach statistical significance (RR 1.07, 95 p.c. CI 0.98, 1.17). Side effect profile was substantially better for atosiban compared to beta-agonists. Conclusions: Oxytocin antagonists appear to be effective and safe for tocolysis in preterm labour.

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    Tytuł oryginału: Totally endoscopic bilateral internal thoracic artery bypass grafting in a young diabetic patient.
    Autorzy: Dogan Selami, Aybek Tayfun, Khan Mohammad Fawad, Neidhard Gerd, Auch-Schwelk Wolfgang, Moritz Anton, Wimmer-Greinecker Gerhard
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.CS95-CS97, il., bibliogr. 11 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • kardiologia
  • endokrynologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: The introduction of robotics into cardiosurgical practice in 1998 has enabled totally endoscopic closed chest procedures. Totally endoscopic grafting of the LAD (TECAB) is no longer an experimental procedure. Case report: We report on case with totally endoscopic bilateral thoracic artery bypass grafting to the left anterior descending and right coronary artery in a 36-year-old obese female diabetic patient using the daVinci surgical system. The patient, suffering from juvenile diabetes for 26 years, presented with stable angina (CCS class II). A coronary angiogram revealed 2-vessel disease with a long complex proximal lesion of the left anterior descending artery (LAD) (90 p.c.) and 80 p.c. stenosis of the proximal right coronary artery (RCA). Due to the condition of the proximal LAD (high risk PTCA with rather poor prognosis), the patient was referred for minimally invasive operative revascularization of the LAD and the RCA. After informed consent was obtained the patient underwent totally endoscopic double internal thoracic artery bypass revascularisation on the arrested heart using computer-enhanced telemanipulation technology. Conclusion: The feasibility and safety of successful closed chest, totally endoscopic double coronary bypass grafting with two internal thoracic arteries is demonstrated in this case. Preservation of a stable chest cavity and reduced risk for wound healing complications in diabetics with an excelent cosmetic result are the obvious advantages of the techniques described.

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    Tytuł oryginału: Lectins as markers for blood grouping.
    Autorzy: Khan Fauzia, Khan Rizwan H., Sherwani Asma, Mohmood Sameena, Azfer Md. Asim
    Źródło: Med. Sci. Monitor 2002: 8 (12) s.RA293-RA300, tab., bibliogr. 114 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • hematologia

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Lectins are unique proteins of varying biological importance. They are characterized by specific binding to carbohydrate residues, whether monosaccharides, disaccharides or polysaccharides. The sugar heads on the surface of the erythrocyte specify the different blood groups. Lectins, as an antigenic determinant of blood group, have come to be an important tool in the identification of different blood groups. A handful of lectins may be considered excellent reagents for anti-A, anti-B, anti-N etc, but the anti-A and anti-M are not yet regarded as compmercially suitable anitsera, Lectin from Vicia cracca, has been proved to be a good anti-A, lectin from Colichus biforus can be used as anti-A1, and lectin from Griffonia simplicifolia as anti0B. Lectin from Vicia graminea is said to be a good typing reagent as Anti-N. On the other hand, the lectins involved in polyagllutination are absolutely essential as the reagent of choice and these cannnot as yet be replaced by antibodies of any kind. Erythrocytes with exposed cryptantigens are significantly more sensitive to agglutination by certain lectins than by polyclonal antibodies. Peanut agglutinin (PNA), Polybrene, and Glycine max lectins are frequently used for the indetification of different cryptantigens. The application of lectins as an anti-B reagent has proven to be a useful as human polyclonal or mouse monoclonal antibodies. Besides their specificity, lectins are excellent reagents because of their lower cost and indigenous production. The importance of various lectins used as markers for blood grouping is discussed.

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