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Tytuł oryginału:
Proinflammatory cytokines in injured rat brain following perinatal asphyxia.
Autorzy:
Maślińska
Danuta,
Laure-Kamionowska
Milena,
Kaliszek
Agnieszka,
Makarewicz
Dorota
Źródło:
Folia Neuropathol. 2002: 40 (4) s.177-182, il., tab., bibliogr. 39 poz.
Sygnatura GBL:
304,961
Hasła klasyfikacyjne GBL:
immunologia
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć męska
płeć żeńska
Streszczenie angielskie:
In contrast to astrogliosis, which is common to injuries of the adult CNS, in the developing brain this process is minimal. Reasons postulated for this include the relative immaturity of the immune system and the consequent insufficient production of cytokines to evoke astrogliosis. To explore this hypothesis, the study was undertaken to detect the presence of some proinflammatory cytokines in the injured rat brain following perinatal asphyxia (ischaemia/hypoxia). The localisation of TNF-ŕ, IL-15, IL-17 and IL-17 recpetors was visualised by means of immunohistochemistry. In numerous neurones of the rat brain, the IL-17 appeared to be constitutively expressed. In the early period of inflammation the IL-15 was produced mainly by the blood cells penetrating the injured brain but later it was synthesised also by reactive astrocytes surroundding brain cysts and forming dense astrogliosiss around necrotic brain regions. The direct effect on astrogliosis of other estimated cytokines seems to be negligible. All the results lead to the conclusion that from all cytokines identified in the injured immature rat brain the IL-15 plays the most important role during inflammatory response and participates in the gliosis of reactive astrocytes.
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