Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: JUREWICZ
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: TRAIL induces death of human oligodendrocytes isolated from adult brain.
Autorzy: Matysiak Mariola, Jurewicz Anna, Jaskólski Dariusz, Selmaj Krzysztof
Źródło: Brain 2002: 125 (11) s.2469-2480, il., bibliogr. [41] poz.
Sygnatura GBL: 300,909

Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce apoptosis in various tumour cell lines and, recently, also in normal cells. TRAIL interacts with four receptors: two signalling receptors (TRAIL-R3 and TRAIL-R4). We have shown that both signalling receptors are present on the surface of oligodendrocytes isolated from adult human brain (ahOL), whereas the decoy receptors are expressed at a low level on ahOL. TRAIL induces ahOL apoptosis - as charcterized by Annexin V staining prior to propidium ioddide cell uptake - under conditions of protein synthesis inhibition. However, pretreatment of ahOL with interferon ç (IFNç) evoked susceptibility to TRAIL-induced death, which did not require inhibition of protein synthesis. A blocking experiment with monoclonal antibodies directed gainst TRAIL-R1 and TRAIL-R2 revealed that TRAIL-R1 is mainly involved in TRAIL-induced apoptosis of ahOL. In contrast to ahOL, microglial cells were completely resistant to cell death induced by TRAIL. Microglial cells had high surface expression of the decoy receptor TRAIL-R3, suggesting that resistance of these glial cells to TRAIL-induced death depends onthe presence of the protective effect of TRAIL-R3. Stimulation of microglia with TRAIL increased further expression of TRAIL-R3, but it had no effect on the expression of TRAIL receptors by ahOL. This result may implicate TRAIL as an effector-immune molecule in selective ahOL demise in inflammatory/demyelinating conditions.

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    Tytuł oryginału: Kliniczne i farmakoekonomiczne porównanie takrolimusu i mikroemulsji cyklosporyny w przeszczepianiu nerek.
    Autorzy: Jurewicz W. A[dam]
    Źródło: Nefrol. Dializ. Pol. 2002: 6 (4) s.241-242, tab., bibliogr. 2 poz.
    Sygnatura GBL: 313,411

    Hasła klasyfikacyjne GBL:
  • transplantologia
  • farmacja
  • nefrologia
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie

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