Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Liczba odnalezionych rekordów: 3



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Tytuł oryginału: G-CSF administered in time-sequenced setting during remission induction and consolidation therapy of adult acute lymphoblastic leukemia has beneficial influence on early recovery and possibly improves long-term outcome: a randomized multicenter study.
Autorzy: Hołowiecki Jerzy, Giebel Sebastian, Krzemień Sławomira, Krawczyk-Kuliś Małgorzata, Jagoda Krystyna, Kopera Małgorzata, Hołowiecka Beata, Grosicki Sebastian, Hellmann Andrzej, Dmoszyńska Anna, Paluszewska Monika, Robak Tadeusz, Konopka Lech, Maj Stanisław, Wojnar Jerzy, Wojciechowska Maria, Skotnicki Aleksander, Baran Wojciech, Cioch Maria
Źródło: Leuk. Lymphoma 2002: 43 (2) s.315-325, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 312,939

Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny
  • praca opublikowana za granicą

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Sixty-four untreated adult acute lymphoblastic leukemia (ALL) patients were randomized to receive chemotherapy alone, n = 31 or chemotherapy and granulocyte colony stimulating factor (G-CSF), n = 33. During induction patients received G-CSF for 5 days between four weekly Epirubicin + Vcradministrations, starting 36 h after each application and finishing 48 h before the next one with the intention to possibly generate a cell cycle dependent protection of normal hematopoietic progenitors and to stimulate granulopoiesis. The complete remission (CR) rate equaled 94 p.c. in the G-CSF group and 87 p.c in controls. Patients who received G-CSF, if compared to the controls, had shorter granulocytopenia during induction and consolidation, displayed a lower infection rate, completed the induction-consolidation quicker and stayed shorter in hospital during induction, p 0.001 - 0.04. Follow-up at 2 years revealed a rather higher probability of survival (59 vs. 27 p.c., p = 0.04) and a lower relapse rate (32 vs. 60 p.c.) in G-CSF arm than in controls. The beneficial influence of G-CSF administered in time-sequenced fashion on survival needs further confirmation.

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    Tytuł oryginału: Comparison of tchniques permitting to detect apoptosis in situ.
    Autorzy: Drąg-Zalesińska M[ałgorzata], Wysocka T[eresa], Dumańska M[ałgorzata], Jagoda E[wa], Zabel M[aciej]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.125-126, il., tab., bibliogr. 4 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Several morphological and biochemical techniques are inuse for identification of apoptotic and necrotic cells ina studied cell population. It is essential to define not only the type of cell death but also to identify the apoptotic process itself, which represents a multistage, active processes, requiring activation of a molecular event cascade. In the present study, we have examined and discussed effectiveness of the selected techniques detecting apoptosis in hymphocytes exposed to incubation at an elevated temperature. The appraisal involved detection of caspase-3 active form, detection of Bel-2, TUnel reaction, the comet assay and electrophoresis of DNA.

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    Tytuł oryginału: Value of PCR technique in detection of Helicobacter pylori in paraffin-embedded material.
    Autorzy: Ciesielska U[rszula], Jagoda E[wa], Marciniak Z[ofia]
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (2) s.129-130, il., tab., bibliogr. 6 poz. - 37 Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików Kraków 02-05.09. 2001
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Methods which permit effective detection of Helicobacter pylori are based on endoscopic sampling of gastric mucosa followed by a direct or indirect demonstration of Helicobacter pylori bacilli, e.g. searching for specific proteins or gene fragments. PCR technique represents one ot techniques employed for diagnosing the biopsies. The present study was aimed at examining how effective is the detection of Helicobacter pylori in paraffin-embedded material by PCR technique using primers for the Ure C gene fragment. The material for studies involved gastric biopsies, routinely fixed in formalin and embedded in paraffin. In order to perfirm PCR, DNA was isolated and purified, subjected to amplification with the use of starters for the Ure C gene fragment. The performed experiments have confirmed suitability of PCR technique for detection of Helicobacter pylori.

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