Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: JĘDRZEJUK
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Prewencja i terapia alternatywna do HTZ u kobiet po operacji raka gruczołu piersiowego.
Tytuł angielski: Prevention and alternative treatment to HRT in women after breast cancer surgery.
Autorzy: Milewicz Andrzej, Jędrzejuk Diana, Lwow Felicja
Źródło: Terapia 2002: 10 (6) s.19-23, bibliogr. 15 poz., sum.
Sygnatura GBL: 313,048

Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo
  • onkologia

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: In Poland approximately 5000 women after breast cancer surgery present every year with severe menopausal complaints and resulting metabolic consequences, i.e. increased risk and mortality rate of cardiovascular disease and osteoporosis. About 75 p.c. of women demonstrate menopause prior to the diagnosis of cancer. For that reason prevention and treatment alternative to HRT tailored to every patietn's needs are so important. The determination of risk factors of cardiovascular disesase (obesity, glycaemia, lipid disorders, hypertension) and osteoporosis (WHO guidelines) is of utmost importance. Risk factors revealed in a ptient determine further preventive management and pharmacotherapy.

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    Tytuł oryginału: Serum leptin levels in acromegaly - a significant role for adipose tissue and fasting insulin/glucose ratio.
    Autorzy: Bolanowski Marek, Milewicz Andrzej, Bidzińska Bożena, Jędrzejuk Diana, Daroszewski Jacek, Mikulski Emil
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR685-CR689, il., tab., bibliogr. 25 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Leptin plays an important role in controlling safety and mainatining energy balance. Acromegaly is characterized by decreased fat, which increases after the disease is cured. Out objective was to investigate serum leptin in acromegaly in terms of disease activity, body fat content, insulin and glucose levels, and selecated anthropometric variables. Mateirl/Methods: We examined 40 patietns with acromegaly and 200 sex- adn age-matched controls for the levles of serum GH, IGF-I, leptin, glucose, and insulin, and for body composition by DEXA, BMI and WHR. In 10 cases the acute ef fect on serum leptin of a somatostatin analogue, lanreotide, was studied. Results: We observed lower elptin in patients with active acromegaly than in cured patients and controls. Body fat was higher in cured than active patients. In the patients, we found significant correlations (p 0.05) between leptin and percent body fat (r = 0.77), leptin and body fat mass (r = 0.74), leptin and fasting insulin (r = 0.62), leptin and fasting insulin/glucose ratio (r = 0.97), leptin adn BMI (r = 0.44), leptin and height (r = -0.47). In the controls there was a significant correlation (p 0.05) o0nly between leptin and WHR (r = -0.45). A paradoxical decrease of the leptin after lanreotide was observed in ;7 out of 10 patients with active acromegaly. Conclusions: Changes in leptin release in acromegaly are related to differences in body fat content and mass, and in insulin resistance. Leptin in acromegaly is not influenced directly by GH or IGF-I secretion. The acute effect of medical treatment of acromeagly by a somatostatin analogue on leptin levels differes from teh effect of a radical cure following pituitary adenoma surgery.

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