Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: HOŁY
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: L-AP4, a potent agonist of group III metabotropic glutamate receptor, decreases central action of angiotensin II.
Autorzy: Fedosiewicz-Wasiluk Małgorzata, Hoły Zdzisław Z., Wiśniewski Konstanty
Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.415-422, il., bibliogr. 32 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The study was designed to investigate the role of the activation of class III metabotropic glutamate receptors (mGluRs) in the behavioral activity of angiotensin II (AngII). The experiments were performed on adult male Wistar rats. Stimulation of group III mGluRs was evoked by icv injection of agonist, L-2-amino-4-phosphonobutyric acid (L-AP4) (5 ćl of 80 mM solution of L-AP4). Fifteen minutes later, the animals were given icv solution containing 1 nmol of AngII. Memory motivated affectively was evaluated by passive avoidance and active avoidance responses (CARs). Moreover, the speculative influence of the treatment on motor activity was tested in open field. We observed that both compounds did not have significant influence on motor activity of rats in open field tesrt. L-AP4 given alone had no influence on acquisition, consolidation and recall of passive avoidance responses. Examination of influence of L-AP4 on the acquisition of CARs, while it did not alter extinction of these responses. AngII, as repeatedly shown before, greatly increased passive avoidance latency, rate of acquisition of CARs and decreased they extinction. Pretreatment of rats with L-AP4 prevented all above behavioral effects of the AngII administration.

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    Tytuł oryginału: Polymorphism in intron 23 of the endothelial nitric oxide synthase gene (NOS3) is not associated with hypertension.
    Autorzy: Derebecka Natalia, Hołysz Marcin, Dankowski Rafał, Wierzchowiecki Michał, Trzeciak Wiesław H.
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.263-268, il., tab., bibliogr. 12 poz.
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Nitric oxide (NO) is synthesised in the vascular endothelium by nitric oxide synthase (NOS3) and is an important factor in the regulation of blood pressure. Imapired synthesis of NO due to mutations in the NOS3 gene is associated with hypertension. To date several allelic variants of the NOS3 gene have been identified and their possible linkage with hypertension investigated. We studied the distribution of genotypes and frequency of alleles of the G11T polymorphism in intron 23 of the NOS3 gene in patients with hypertension and in a control groups of healthy individuals. The polymorphism was determined by PCR-RFLP analysis. The distribution of genotypes in the patients with hypertension and in the healthy individuals did not differ significantly from the values predicted from Hardy-Weinberg equilibrium for the general population. No major differences in the distribution of the G11T polymorphsm in the patients and healthy individuals were found (P 0.05).

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    Tytuł oryginału: Samobójstwo
    Opracowanie edytorskie: Hołyst Brunon (red.), Staniaszek Marek (red.), Binczycka-Anholcer Marzena (red.).
    Polskie Towarzystwo Higieny Psychicznej
    Źródło: - Warszawa, PTHP 2002, 339, [1] s. : il., tab., 21 cm.
    Sygnatura GBL: 735,731

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

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