Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Liczba odnalezionych rekordów: 4



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Tytuł oryginału: Potential for immune reconstitution through G-CSF treatment of HIV patients.
Autorzy: Aulock Sonja von, Hartung Thomas
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (2) s.111-120, il., bibliogr. 90 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:
  • farmacja
  • aIDS
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: New treatment strategies for HIV/AIDS are very successful in reducing viral load. However, reconstitution of the immune system takes about one year and may be insufficient or remain incomplete. During this time the patient remains prone to opportunistic infections as a result of the complex immune dysfunction caused by the virus. Recombinant granulocyte colony-stimulating factor (G-CSF) has diverse immunomodulatory properties which may be beneficial in aiding immune reconstitution.

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    Tytuł oryginału: Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
    Autorzy: Ellingsen Espen A., Morath Siegfried, Flo Trude H., Schromm Andra B., Hartung Thomas, Thiemermann Christoph, Espevik Terje, Golenbock Douglas T., Foster Simon J., Solberg Rigmor, Aasen Ansgar O., Wang Jacob E.
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR149-BR156, il., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • mikrobiologia
  • farmacja
  • hematologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Pro-inflammatory potential of lipoteichoic acid (LTA) from Staphylococcus aureus is controversial. Present study was undertaken to examine ability of highly purified and characterized S. aureus LTA to stimulate production of pro-inflammatory cytokines in human leukocytes at both mRNA and protein level, and to study involvement of Toll-like receptors (TLRs) adn CD14 in this response. Purified LTA was administered to whole human blood ex-vivo (or primary adherent monocytes) and cytokine response assessed in plasma by EIA. Cytokine mRNA was measured by RT-PCR on leukocyate subsets isolated following stimulation. To study involvement of specific receptors for LTA signaling, CHO cells transfected with CD14 and/or TLR2, TLR4 were used, as well as antibodies directed against these receptors. Addition of highly purified LTA to a whole blood or primary adherent monocytes elicited a time and concentration dependent release of TNF-ŕ, IL-1á, IL-6 and IL-8. mRNA encoding TNF-ŕ, IL-1á, IL-6 and IL-8. mRNA encoding TNF-ŕ, IL-1á and IL-6 seemed to be accumulated in monocytes and T cells, but not in granulocytes and B cells. Expression of TLR2, but not TLR4, in chinese hamster ovary cells conferred responsiveness to LTA. However, antibodies directed towards TLR2 (clone TL2.1) or TLR4 (clone THA125) failed to inhibit TNF-ŕ release induced by LTA in the whole blood model and in adherent monocytes. In contrast, blockade of the CD14 receptor with MAb18D11 strongly attenuated LTA induced release of TNF-ŕ in both models.

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    Tytuł oryginału: Air contaminants in different European farming environments.
    Autorzy: Radon Katja, Danuser Brigitta, Inversen Martin, Monso Eduard, Weber Christoph, Hartung J”rg, Donham Kelley J., Palmgren Urban, Nowak Dennis
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (1) s.41-48, il., tab., bibliogr. 37 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • medycyna pracy
  • pulmonologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Farmers are known to be at high risk from the development of occupational airway disease. The first stage of the European farmers' study has shown that pig farmers in Denmark and Germany, poultry farmers in Switzerlad and greenhouse workers in Spain were at highest risk for work-related respiratory symptoms. Therefore, the aim of this study was to determine exposure levels at relevant farm workplaces. Dust and endotoxin levels as well as microbiological concentrations were determined in 213 crop and animal farming environments by personal sampling. The highest total dust concentrations were found in poultry houses in Switzerland with median concentrations of 7.01 mg/m**3. The median airborne endotoxin concentrations in total dust ranged between 0.36 ng/m**3 in Spanish greenhouses and 257.58 ng/m**3 in poultry houses in Switzerland. Likewise, the highest median concentrations of total (2.0 x 10**7 cells/m3) and active fungi (4.4 x 10**5 cfu/m**3) have been found in Swiss poultry houses. The predominant fungus taxa discovered in poultry houses were Eurotium spp. and thermophilic fungi. Cladosporium and Botrytis were mainly detecated in greenhouses. The exposure level found in this study might put the farmers at risk from respiratory diseases.

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    Tytuł oryginału: Prevalence and risk factors for airway diseases in farmers - summary of results of the European Farmers' Project.
    Autorzy: Radon Katja, Monso Eduard, Weber Christoph, Danuser Brigitta, Iversen Martin, Opravil Ulrike, Donham Kelley, Hartung J”rg, Pedersen Soeren, Garz Susanne, Blainey David, Rabe Uta, Nowak Dennis
    Źródło: Ann. Agric. Environ. Med. 2002: 9 (2) s.207-213, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 313,158

    Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca epidemiologiczna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The aim of the European Farmers' Project was to determine prevalence and risk factors of respiratory diseases in farmers across Europe. A cross-sectional study in 7 centres was carried out. In the first stage of the study, nearly 8000 farmers in Denmark, Germany, Switzerland, the UK, and Spain answered a standardised questionnaire on farming characteristics and respiratory symptoms. The second stage of the study included exposure assessment and lung function measurements in 4 of the centres. Within the group of farmers, pig farmers were at high risk of asthma-like syndrome as compared to farmers keeping other kinds of animals. Among plant farmers, greenhouse workers were at higher risk for symptoms of asthma. The prevalence of symptoms of allergies were significantly lower among animal farmers as compared to the population of the European Community Respiratory Health Survey. In contrast, animal farmers had a signifcantly higher prevalence of symptoms of chronic bronchitis. The major risk factor for respiratory symptoms was shown to be ventilation of the animal houses and greenhouses. Intervention studies are now warranted to test the effectiveness of improved ventilation on respiratory health. The reasons for the low prevalence of allergic diseases among farmers are currently under study.

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