Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: GWIEŹDZIŃSKI
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: Levels of F1+2 prothrombin fragments and thrombin - antithrombin III (TAT) complexes in patients with dermatitis herpetiformis.
Autorzy: Wankiewicz Anna, Iwan-Ziętek Iza, Gwieździński Zenon, Kotschy Maria
Źródło: Med. Sci. Monitor 2002: 8 (8) s.BR324-BR327, tab., bibliogr. 14 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • hematologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Dermatitis herpetiformis (DH) is a rare bullous disease of autoimmune etiology. It is an intestinocutaneous syndrome, in which vesicopapular cutaneous lesions are accompanied by gluten-dependent enteropathy. The diagnosis of DH is based on immunopathological investigation of unaffected skin fragment (granular IgA deposits present at the tops of dermal papillae and IgA - EMA present in the serum). Material/Methods: The studied group consisted of 33 patients with dermatitis herpetiformis - 23 males and 10 females aged 22-78 (mean age 44.7). In all the patients, the following parameters of blood coagulation systems were determined in the plasma levels of prothrombin fragments 1+2 (F1+2), levels of thrombin - antithrombin III (TAT) complexes, antithrombin III activity (AT III). Results: In patients with dermatitis herpetiformis, the main level of F1+2 fragments amounted to 9.08 nmol/l, as compared with 1.14 nmol/l in the control group (the difference statistically significant, p 0.0001). In DH patients, the levels of TAT complexes were over twice higher than among the controls and that difference also reached statistical significance (p 0.0001). Mean antithrombin III activity (AT III) in patients with DH reached 102.60 p.c. and was similar to that observed in the control group (104.68 p.c.) Conclusions: In patients with dermatitis herpetiformis, increased levels of F1+2 prothrombin fragments and TAT complexes indicate enhanced in vivo thrombinogenesis. No statistically significant differences of F1+2 TAT and AT III levels in DH patients related to their sex, age and duration of the disease were observed.

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    Tytuł oryginału: Selected parameters of fibrinolysis system in patients with dermatitis herpetiformis.
    Autorzy: Wankiewicz Anna, Iwan-Ziętek Iza, Kotchy Maria, Gwieździński Zenon
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR189-CR192, tab., bibliogr. 8 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Dermatitis herpetiformis (DH) is a very rare bullous dermatitis of autoimmune origin. It is a sydnrome involving dermal and intestinal pathology, in which vesicopapular skin lesions are accompanied by gluten-dependent enteropathy. The diagnosis of DH is based on immunopathological investigation of unaffected skin bioptate (presence of granular IgA deposits in the upper portions of dermal papillae). Materia/Methods: The study was carried out in a group of 33 patients, including 23 males and 10 females aged 22-78 (mean age 44.7 years). The following fibrinolysis system parameters were determined in the sera of all patients: tissue plasminogen activator concentration (t-PA: Ag), urokinase plasminogen activator concentration (u-PA: Ag), plasminogen activator inhibitor concentration (PAI-Ag), plasminogen level, alpha-2 antiplasmin activity (ŕ-2-AP), plasmin - alpha-2 antiplasmin complexes concentration (PAP). Results: Mean t-PA concentration in DH patients was 5.52 ng/ml, vs.4.8 ng/ml in controls. The respective u-PA concentrations amounted to 0.33 ng/ml, and 0.39 ng/ml. PAI-1 concentration was markedly higher in DH patietns (36.2 ng/ml) than in controls (22.40 ng/ml), whereas plasminogen level was significantly lower (86.0 p.c. vs. 115.9 p.c.). In patients, ŕ-2-AP activity was 92 p.c. and was ower than in controls - 103.4 p.c. DH patients demosntrated also higher concentrations of PAP complexes (327.45 ng/ml) than the control group (203.03 ng/ml). Conclusions: Patietns with DH were found to have lower plasminogen and ŕ-2 antiplasmin levels and increased concentrations of PAP complexes, which indicates increased plasminogenesis n vivo. Increased type 1 plasminogen activator inhibitor level (PAI-1) may reflect a chronic inflammatory condition present in DH patients.

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    Tytuł oryginału: Zakażenia grzybicze skory i błon śluzowych - nowoczesna terapia grzybic.
    Autorzy: Gwieździński Zenon
    Źródło: Zakażenia 2002 (3/4) s.52, 54-58, 60, il., tab., bibliogr. 35 poz.
    Sygnatura GBL: 313,628

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • dermatologia i wenerologia

    Wskaźnik treści:
  • ludzie

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