Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: GRYNKIEWICZ
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Metabolity wtórne i aktywność biologiczna złocienia maruny (Tanacetum parthenium L.).
Tytuł angielski: Secondary metabolites and biological activity of feverfew (Tanacetum parthenium L.).
Autorzy: Grynkiewicz Grzegorz, Gadzikowska Maria
Źródło: Post. Fitoter. 2002: 3 (3/4) s.64-69, il., bibliogr. 50 poz., sum.
Sygnatura GBL: 313,535

Hasła klasyfikacyjne GBL:
  • farmacja

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: A short review of Tanacetum parthenium as a phytochemical raw material and possible sources of individual active constituents is presented. Traditional applications of feverfew, culminating with modern clinical trials of migraine treatment and prophylaxis, are discussed in juxtaposition to current results in biochemistry and molecular pharmacology of the principal sesquiterpenoid component- parthenolide.

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    Tytuł oryginału: Syntezy naturalnych i modyfikowanych antybiotyków antracyklinowych ze wspólnego prekursora: 3,4-di-O-acetylo-L-ramnalu.
    Tytuł angielski: Syntheses of natural and modified anthracycline antibiotics from a common precursor: 3,4-di-O-acetyl-L-rhamnal.
    Autorzy: Grynkiewicz Grzegorz, Achmatowicz Osman, Fokt Iza, Priebe Waldemar, Ramza Jan, Szechner Barbara, Szeja Wiesław
    Źródło: Wiad. Chem. 2002: 56 (7/8) s.535-560, il., sum.
    Sygnatura GBL: 310,575

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna

    Streszczenie angielskie: While natural anthracycline antibiotics retain their possition of clinically important antitumor drugs despite their serious side effects, much effort is directed towards their improvement by rational structural changes. Most of useful anthracycline antibiotics chemistry is done by dissconnectionmodification approach, followed by de novo glycosidic bond assembly. It is pointed out that 1,2- and 2,3-unsaturated pyranosides constitute an important class of intermediates, useful for synthesis of natural and modified antibiotic aminosugars. Glycals derived from 3-amino-2,3,6-trideoxypyranoses and their 1-O-silylated derivatives are useful glycosyl donors for a variety of alcohols. Also anthracycline antibiotics can be obtained from them in simple preparative procedures which are amenable for scale up and technical process development. Moreover, unsaturated pyranoses from 6-deoxy-L-configurational series are useful chiral precursors for anthracycline aglycons synthesis. Remarkably, various synthetic schemes comprising anthracycline antibiotic sugars, aglycons and new synthetic analogues can be traced down to the single common precursor: 3,4-di-O-acetyl-L-rhamnal, easily obtained from a commodity chemical (raw material in food industry) L-rhamnose.

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