Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
FALCIONI
Liczba odnalezionych rekordów:
2
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1/2
Tytuł oryginału:
Effect of NADH on the redox state of human hemoglobin.
Autorzy:
Olek
Robert A.,
Antosiewicz
Jędrzej,
Caulini
Gian Carlo,
Falcioni
Giancarlo
Źródło:
Clin. Chim. Acta 2002: 324 (1/2) s.129-134, il., bibliogr. 15 poz.
Sygnatura GBL:
303,881
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
in vitro
Streszczenie angielskie:
In this work, we report that NADH can increase the autoxidation rate of hemoglobin (HbA) in a pH-dependent fashion. During this process, this cofactor is itself oxidized. The presence of superoxide dismuatase (SOD) and/or catalase (CAT) can inhibit this result. At lower pH rates, the effect of NADH on the hemoglobin autoxidation rate is more enhanced, in addition, the rate of NADH oxidation is increased. Our data indicates that the reduced pyridine nucleotide may influence the redox state of human hemoglobin by a mechanism, which probably involvews free radical species.
2/2
Tytuł oryginału:
Divergent effects of quinolinic aminoxyls on mitochondrial ultrastructure and localisation in osteosarcoma 143 B cells.
Autorzy:
Spodnik
Jan Henryk,
Kędzior
Jakub,
Gil
Aleksandra,
Woźniak
Michał,
Wakabayashi
Takashi,
Falcioni
Giancarlo,
Greci
Lucedio
Źródło:
Folia Morphol. 2002: 61 (4) s.261-264, il., bibliogr. 18 poz.
Sygnatura GBL:
301,720
Hasła klasyfikacyjne GBL:
farmacja
onkologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
in vitro
Streszczenie angielskie:
In the present study we have shown that quinolinic aromatic aminoxyls are very efficient in protecting lipids of endoplasmic reticulum membranes against hydroperoxide-induced oxidation. The efficacy of these aminoxyls as protectors of lipids was much higher than the water-soluble 4-OH-TEMPO. We have also shown that QAL causes distinct changes of the morphology of mitochondria: from filamentous to granular enlarged structure via the folding of the former. QAL induces also perinuclear clustering of mitochondria. C-QAL as well as 4-OH-TEMPO treated cells revealed filamentous and scattered pattern of mitochondria. Antioxidant activity of QAL as well as morphological changes of mitochondrial raise the possibility that this drug can affect cell physiology via changes of mitochondrial function.
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