Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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DANILCZUK
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Tytuł oryginału:
Effect of imipramine on brain D-1 and 5-HT-2A receptors in a chronic unpredictable stress model in rats.
Autorzy:
Ossowska
Grażyna,
Nowak
Gabriel,
Klenk-Majewska
Bożena,
Danilczuk
Zofia,
Żebrowska-Łupina
Iwona
Źródło:
Pol. J. Pharmacol. 2002: 54 (2) s.89-93, tab., bibliogr. 40 poz.
Sygnatura GBL:
313,156
Hasła klasyfikacyjne GBL:
farmacja
neurologia
psychiatria i psychologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
Streszczenie angielskie:
Chronic unpredictable stress (CUS) model of depression is one od the well validated animal models of depression. In this paper, we report the results of investigations into dopaminergic D-1 and serotonergic 5-HT-2A receptors in the brain of rats subjected to CUS procedure and treated chronically with imipramine. We have examined the dopaminergic D-1 ([3H-SCH 23390) in the limbic area and serotonergic 5-HT-2A ([3H-ketanserin) receptors in the cerebral cortex by a saturation radioligand binding method in rats subjected to CUS paradigm, imipramine, both CUS and imipramine and control animals. CUS procedure resulted in a significant 36 p.c. increase in the D-1 receptor density in the limbic system, which was attenuated by chronic imipramine treatment. Also a 21 p.c. increase in the density of 5-HT-2A receptors in the cerebral cortex induced by CUS was reduced by chronic imipramine treatment. The present data indicate that the increases in the density of brain D-1 and 5-HT-2A receptors of rats subjected to CUS, which are "normalized" by imipramine, might be involved in the pathophysiology of :animal depression" (and, thus, in pathophysiology of human depression) and in the mechanism of antidepressant tharapy.
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Tytuł oryginału:
Repeated treatment with selective serotonin reuptake inhibitors but not anxiolytics prevents the stress-induced deficit of fighting behavior.
Autorzy:
Ossowska
Grażyna,
Żebrowska-Łupina
Iwona,
Danilczuk
Zofia,
Klenk-Majewska
Bożena
Źródło:
Pol. J. Pharmacol. 2002: 54 (4) s.373-380, il., tab., bibliogr. 46 poz.
Sygnatura GBL:
313,156
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
badanie porównawcze
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć męska
Streszczenie angielskie:
Several animal models of "depression" have been examined. One of them is chronic unpredictable stress (CUS)-induced deficit of fighting behavior in rats. In the present study, we compared the effects of two antidepressants (fluoxetine or fluvoxamine) and three anxiolytics (buspirone, lorazepam or oxazepam) on the electric footshock-induced fighting behavior in the pairs of male Wistar rats exposed to CUS procedure (16-day application of various unpredictable stressors). It was found that, in chronically stressed rats, the number of fighting attacks was significantly reduced (by about 70 p.c.). Prolonged (for 14 days) treatment of rats with fluoxetine or fluvoxamine (both at the dose of 10 mg/kg/day) counteracted the deficit of aggression induced by the chronic stress,. On the contrary, the anxiolytics: lorazepam (0.5 mg/kg/day), oxazepam (5 mg/kg/day) or buspirone (0.2 mg/kg/day) administered for 14 days, did not modify the deficit of fighting induced by CUS procedure. It must be underlined that prolonged treatment with all used drugs did not change the intensity of fighting in normal (unstressed) rats. In conclusion, prolonged tratment with antidepressant drugs prevents the CUS-induced deficit of fighting behavior, whereas no beneficial effect of anxiolytic agents was found.
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