Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: CHOCHOLSKA
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Survival of the patient with the small-cell lung cancer and the state of his immunological response. Short report.
Autorzy: Krawczyk Paweł, Mackiewicz Barbara, Chocholska Sylwia, Milanowski Janusz
Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.145-150, il., bibliogr. 10 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
Sygnatura GBL: 304,313

Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: In the moment of diagnosis, small-cell lung cancer (SCLC) is a generalised disease due to the metastatic spread. The antitumour cytotoxic immunological response may control the development of SCLC growth because of an easy contact with neoplasm antigens. The aim of the study was to evaluate the activity state of the cytotoxic T-lymphocytes (CTLs) in a 52-years-old male patient with a 24-month course of SCLC. In the research, the flow cytometric technique was used. The percentage of CTLs in our patient was two times higher (29,64 p.c.) comparing to other patients with SCLC (N=5; 9.90 p.c. ń 4.14 p.c.) and healthy donors (N=10; 9,34 ń 4.07 p.c.). The expression of FasL on the CTLs surface was 49.15 MFI in the patient with a long course of SCLC, 12,86 ń 1.81 MFI in other patients with SCLC and 14.62 ń 3.54 MFI in the control group. It seems that specific clones of CTLs generated in SCLC may have an influence on the prolongation of patient's survival.

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    Tytuł oryginału: Is the lung cancer among the hereditary malignancies?
    Autorzy: Krawczyk Paweł, Michnar Marek, Kieszko Robert, Król Anna, Wójcik Magdalena, Chocholska Sylwia, Milanowski Janusz
    Źródło: Bull. Vet. Inst. 2002: [46] suppl. s.151-157, il., bibliogr. 17 poz. - 2 Międzynarodowe Sympozjum nt. herpes- i retrowirusów - wirusy onkogenne i onkogeneza Puławy 26-27.09. 2002
    Sygnatura GBL: 304,313

    Hasła klasyfikacyjne GBL:
  • genetyka
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Cancer familial agregation (CFA) reflects an inherited predisposition to the development of the benign and malignant tumours. In the classification, the most frequent are the hereditary breast, ovarian and colerated cancers, while the hereditary lung cancer (HLC) is not fully defined as a disorders of a genetic ground. The research involved a group of 92 patients suffering from the lung cancer and one of 80 subjects with chronic obstructive pulmonary disease (COPD) as a control. Information from the questionnaire was used for drawing the genealogies considering the incidence of different types of cancers in the particular family. 19.55 p.c. families fulfilled criteria of CFA and 3.25 p.c. - of HLC in the lung cancer patients group. In contrast with the first group, only 3.75 p.c. families fulfilled the criteria of CFA and 1.25 p.c. families - of HLC in COPD patients group. The patients with lung cancer had greater overall risk of this cancer than the patients with COPD providing that the neoplams appeared in the first-degree relatives (OR=3.09, P=0.037). The crude odds ratio of lung cancer individuals having one family member with lung cancer was 2.25 in comparison with COPD subjects (P=0.05). On the basis of the results above, it can be assumed that the lung cancer may belong to the hereditary malignancies.

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