Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: CHILMONCZYK
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Journal of Pharmacy and Pharmacology
Tytuł polski: Pharmacological properties and SAR of new 1,4-disubstituted piperazine derivatives with hypnotic-sedative activity.
Autorzy: Chilmonczyk Zdzisław, Mazgajska Maria, Iskra-Jopa Joanna, Chojnacka-Wójcik Ewa, Tatarczyńska Ewa, Kłodzińska Aleksandra, Nowak Jerzy Z.
Źródło: J. Pharm. Pharmacol. 2002: 54 (5) s.689-698, il., tab., bibliogr. s. 696-698
Sygnatura GBL: 300,961

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Preparation, pharmacological properties and structure-activity relationships of new pyrimidylpiperazine derivatives, exhibiting sedative and hypnotic activity in mice, are reported. The hypnotic activity of the compounds was comparable with that of zopiclone (the known hypnotic-sedative agent), their interaction with ethanol, however, being much lower. The obtained results suggested that zopiclone and pyrimidylpiperazines 2, 4 and 5 exerted their pharmacological activity through a different mechanism - zopiclone through the interaction with benzodiazepine receptors and compounds 2, 4 and 5 through an unidentified molecular target. The pharmacological properties of compound 3 could be the result of a mixed mechanism of action, combining the properties of zopiclone and those of compounds 2, 4 and 5. A common feature of zopiclone and compounds 2 and 3 was that, after their systemic administration, independently of mechanism of action, together with the hypnotic effect a reduction of the 5-HT turnover in the mouse brain was observed. Minimum structural requirements for the hypnotic activity were formulated. Structural considerations have shown that removing the ŕ-carbonyl group did not influence the drug's ability to inhibit the locomotor activity. However, it did influence its ability to disturb motor coordination or abolish the righting reflex within non-lethal doses.

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    Tytuł oryginału: 5-HT1A receptors. Their role in anxiety and depression mechanism of activation.
    Autorzy: Chilmonczyk Zdzisław
    Źródło: Pol. J. Pharmacol. 2002: 54 (2) s.175-178, il., bibliogr. 38 poz. - 11 Dni Neuropsychofarmakologii Ustroń-Jaszowiec 27-29.05. 2002
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

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