Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: BRODZICKI
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Frequency, consequences and pharmacological treatment of gastroesophageal reflux in children with cystic fibrosis.
Autorzy: Brodzicki Jacek, Trawińska Maria, Korzon Maria
Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR529-CR537, tab., bibliogr. 42 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Gastroesophageal reflux (GER) may aggravate chronic bronchopulmonary diseases. The study evaluated GER frequency and characteristics in children with Cysti Fibrosis (CF) as well as its consequences and pharmacological treatment. Material/Methods: 40 CF children aged 1.3 to 20 years were examined. The study methodology involved: medical files analysis, anamnesis, physical examination, growth status estimation, esophageal pH-metry and upper gastrointestinal tract endoscopy with histological examination of esophageal biopsies. Results: Based on pH-metry results, the diagnosis of GER was established in 22 children (55 p.c.). Mild GER (Index Reflux - IR 5-10 p.c.) was found in 12 children (54.5 p.c.), moderate GER (IR 10-20 p.c.) in 7 (31.8 p.c.) and severe GER (IR 20 p.c.) in 3 (13.6 p.c.). Ten patietns with moderate or severe GER underwent endoscopy, which revealed GER-related esophagitis in 8 cases. There was no statistical difference of GER frequency and degree according to: age, sex, growth status, presence of type DeltaF508 mutation in CFTR genome and typical GERD symptoms. According to the ESPGAN proposition, cisapride or cisapride with ranitidine medication was instituted. Treatment analysis was performed in 19 cases after successful follow-up examinations carried out three months later, indicating a significant decrease in reflux index, the longest episode duration and the numer of episodes longer than 5 minutes. Improvement of endoscopic picture was noticed after treatment. Conclusion: High frequency of gastroesophageal reflux and its consequences among...

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    Tytuł oryginału: TGF-á (transforming growth factor-á) in chronic inflammatory conditions - a new diagnostic and prognostic marker?
    Autorzy: Marek Andrzej, Brodzicki Jacek, Liberek Anna, Korzon Maria
    Źródło: Med. Sci. Monitor 2002: 8 (7) s.RA145-RA151, il., bibliogr. 58 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: TGF-á is a cytokine with varied properties and pleiotropic activity. It is released in an inactive form. To exhibit its biological activity, it requires binding to extracellular matrix proteins and, after that, proteolytic elimination of LAP (Latent Associated Protein) and LTBP (Latent TGF-á Binding Protein). The process involves, among others, tissue transglutaminase, thrombin and plasmin. By stimulation of specific receptors, it influences transcription of some genes and translation of formed mRNA. Locally, it demonstrates proinflammatory properties whereas systemically, it has primarily a potent immunosuppressive effect. TGF-á, by affecting proliferation, differentiation and migration of cells, as well as stmulation of extracellular matrix protein production, plays an important role in tissue regeneration and remodeling, but also in fibrosis. TGF-á is also indispensable to maintain immune homeostasis of the organism. Reduced TGF-á activity is considered to be responsible for development of autoimmune disorders in the course of several pathologic conditions. This cytokine plays an important role in the pathogenesis of chronic inflammatory processes taking place, among others, in inflammatory bowel diseases (IBD) and chronic hepatitis B and C. The paper presents a review of literature concerning diagnostic and prognostic value of TGF-á level determinations in blood and tissue bioptates of patients with chronic non-specific enteritis and chronic hepatitis B and C.

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