Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
BAŃKOWSKI
Liczba odnalezionych rekordów:
4
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1/4
Tytuł oryginału:
Wpływ diklofopu na wybrane enzymy metabolizujące substancje obce w wątrobie szczurów rasy Wistar.
Tytuł angielski:
The effect of diclofop on some drug metabolizing enzymes in the liver of Wistar rats.
Autorzy:
Palut
Danuta,
Kostka
Grażyna,
Wiadrowska
Bożena,
Bańkowski
Robert
Źródło:
Rocz. Państ. Zakł. Hig. 2002: 53 (1) s.1-9, tab., bibliogr. 24 poz., sum.
Sygnatura GBL:
301,906
Typ dokumentu:
praca doświadczalna
Wskaźnik treści:
zwierzęta
szczury
płeć męska
Streszczenie polskie:
Diklofop, herbicyd z grupy pochodnych kwasu fenoksypropionowego, nie wykazuje właściwości induktorów CYP1A i słabo stymuluje aktywność CYP2B w wątrobie szczura. Natomiast wyniki sugerują, że badany związek hamuje aktywność fenolowej formy UDP-glukuronylotransferazy.
Streszczenie angielskie:
The study was designed to determine whether diclofop, introduced to environment as herbicide, would exert properties of chemical inducers of rat liver monooxygenase system related to CYP1A and CYP2B isozymes. For this purpose, the effect ofdiclofop on 7-etoxyresorufin O-dealkylase and p-nitroanisole O-demethylase activities specific for CYP1A as well as on CYP2B mediated 7-pentoxyresorufin O-dealkylase activity was studied in male Wistar rats. This biochemical method permits to determine whether tested compound belongs to one of two main types of chemical inducers. Diclofop was dosed by gavage for 4 days at 0; 5.6, 11.2 and 56 mg/kg b.w. per day. Treatment of rats with diclofop resulted in significant increase in relative liver weight (RLW), to 19 p.c. and 31 p.c. above the control, respectively. Diclofop administered at the dose of 11.2 and 56 mg/kg b.w. per day induced a 3-fold (p 0.001) and a 5=fold (p 0.001) increase in the metabolism of 7-pentoxyresorufin (CYP2B-mediated reaction), respectively. No effect level for CYP2B induction was 5.6 mg/kg b.w. per day. However, diclofop induced only slight increase in 7-etoxyresorufin 0-dealkylase and did not show any effect on p-nitroanisole 0-demethylase activity (CYP1A-mediated reactions). The results revealed that diclofop not show the ability to induce CYP1A and moreover it was weak inducer of CYP2B isozymes in the liver of male Wistar rats. Diclofop was also examined for its ability to affect the activity of phenol UDP-glucuronosyltransferase in rat liver. The results suggest that diclofop suppressed phenol form of...
2/4
Tytuł oryginału:
The effect of pre-eclamptic umbilical cord serum on fibroblast division in culture.
Autorzy:
Pawlicka
Elżbieta,
Romanowicz
Lech,
Bańkowski
Edward,
Chyczewski
Lech,
Jaworski
Stefan
Źródło:
Folia Histochem. Cytobiol. 2002: 40 (4) s.381-384, il., tab., bibliogr. 14 poz.
Sygnatura GBL:
304,846
Hasła klasyfikacyjne GBL:
ginekologia i położnictwo
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
noworodki
dorośli 19-44 r.ż.
płeć żeńska
ciąża
Streszczenie angielskie:
Edema, proteinuria, hypertension (EPH-gestosis), most commonly termed as pre-eclampsia, is the most common pregnancy-associated pathological syndrome. It is accompanied by a through remodelling of extracellular matrix in the umbilical cord tissues. It is commonly known that the presence of serum in culture medium storngly stimulates many functions of cells cultured in vitro. It was decided to check how the pre-eclamptic serum affects the fibroblast division in culture. Ki-67 is a protein present in proliferating cells and can be detected during all phases of the cell cycle (G1, S, G2/M) but not in resting (GO) cells. PCNA (proliferating cell nuclear antigen) is an intranuclear polypeptide whose synthesis rate is at its maximum during the S-phase of the cell cycle. The expression of Ki-67 and PCNA was measured by immunocytochemical methods and biosynthesis of DNA was evaluated by [14C]-thymidine incorporation. The activity of pre-eclamptic umbilical cord serum (UC-serum) was found to be distincly lower in comparison to control one. The expression of Ki and PCNA in fibroblast cultures treated wtih pre-eclaptic serum was also distinctly lower. Also the incorporation of [14C]-thymidine to DNA was lower than in the cultures treated with control UC-serum. It may by concluded that pre-eclampsia reduces the mitogenic activity of the umbilical cord serum.
3/4
Tytuł oryginału:
Patofizjologia : podręcznik dla studentów medycyny
Autorzy:
Bańkowski
Edward,
Bełtowski
Jerzy,
Białkowska
Magdalena,
Chłap
Zbigniew,
Cybulska
Barbara,
Czekalski
Stanisław,
Czokało-Plichta
Maria,
Dąbrowski
Ryszard,
Dzierżkowska
Jolanta,
Fidziańska
Elżbieta,
Fogel
Wiesława A.,
Górnicki
Mirosław,
Górny
Dionizy,
Gujski
Mariusz,
Gumułka
Stanisław W.,
Guzek
Jan W.,
Jagielski
Józef,
Kaleta
Zbigniew,
Kłosiewicz-Latoszek
Longina,
Knapowski
Jan,
Kostowski
Wojciech,
Kotschy
Maria,
Kowalski
Janusz,
Kwarecki
Krzysztof,
Markiewicz
Lech,
Maślińska
Danuta,
Maśliński
Czesław,
Maśliński
Sławomir,
Opuchlik
Andrzej,
Poppe
Paweł,
Ryżewski
Jan,
Szostak
Wiktor B.,
Szukiewicz
Dariusz,
Śródka
Andrzej,
Tchórzewski
Henryk,
Tyrakowski
Tomasz,
Witanowska
Anna,
Wróbel
Jan,
Zaremba
Jacek,
Ziemba
Andrzej W.,
Ziemlański
Światosław,
Zużewicz
Krystyna,
Żarski
Stefan
Opracowanie edytorskie:
Maśliński Sławomir (red.), Ryżewski Jan (red.).
Wydanie:
- Wyd. 3
Źródło:
- Warszawa, Wydaw. Lekarskie PZWL 2002, 1067, [1] s. : il., tab., 24 cm.
Sygnatura GBL:
735,706
Wskaźnik treści:
ludzie
4/4
Tytuł oryginału:
Binding of the basic fibroblast growth factor (bFGF) by soluble components of human umbilical cord.
Autorzy:
Sobolewski
Krzysztof,
Bańkowski
Edward,
Pałka
Jerzy,
Jaworski
Stefan
Źródło:
Acta Bioch. Pol. 2002: 49 (4) s.999-1004, il., bibliogr. s. 1003-1004
Sygnatura GBL:
303,116
Hasła klasyfikacyjne GBL:
ginekologia i położnictwo
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
noworodki
płeć żeńska
ciąża
dorośli 19-44 r.ż.
Streszczenie angielskie:
Pre-eclampsia, the most common pregnancy associated syndrome, is connected with remodelling of extracellular matrix of the ubilical cord tissues. Since the fibroblast growth factor (FGF) is known to be a stimulator of collagen and glycosaminoglycan biosynthesis, one may expect that it plays an improtant role in such a remodelling. Studies performed on the umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass. Pre-eclampsia is associted with a decrease of endogenous FGF-binding by soluble high molecular mass components of the umbilical cord. It is suggested that FGF released from these complexes may be actively bound by fibroblasts of the umbilical cord, stimulting them to produce collagen and sulphated glycosaminoglycans.
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